LRIG1

Across TCGA patient cohorts, LRIG1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIG1-associated genes across cancer lineages are Cyclin-B1, Ku80, and p38-MAPK. Each is linked with LRIG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRIG1-to-partner and partner-to-LRIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LRIG1-low versus LRIG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG1→partner) and Y-score (partner→LRIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.361	+1.273	.022	.007	3	4
UCEC	Ku80 →	+0.162	+1.120	.014	.013	3	3
COAD	p38-MAPK →	+0.273	+3.008	.002	.019	3	2
BLCA	Caspase-7-cleavedD198 →	+0.998	+2.459	<.001	.020	2	3
COAD	G6PD →	+0.377	+3.008	<.001	.019	3	2
COAD	eEF2K →	-0.562	-2.961	.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-B1 by LRIG1 expression — UCEC

Explore this box plot interactively →