LRIG1

Across TCGA cell cohorts, LRIG1 mutation is significantly associated with the RNA expression of many other genes, with 522 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRIG1-associated genes across cancer lineages are MTNR1A, C10orf53, and FAM47A. Each is linked with LRIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIG1-to-partner and partner-to-LRIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTNR1A grouped by LRIG1-low versus LRIG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG1→partner) and Y-score (partner→LRIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTNR1A →	+0.335	+3.064	.002	.009	3	2
CNS	C10orf53 →	+0.054	+3.459	<.001	.006	3	2
BLOOD_Lymphoma	FAM47A →	+0.026	+4.867	<.001	.009	3	2
LUNG_NSCLC_LUAD	TRIM51 →	+0.093	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	IFNA16 →	+0.022	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5J2 →	+0.100	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 522 associations by consensus.

MTNR1A by LRIG1 expression — LARGE_INTESTINE

Explore this box plot interactively →