LRIF1

Across TCGA pan-cancer cohorts, LRIF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRIF1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRIF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRIF1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where LRIF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.104	0.985	.014	14	view →
GBM	DFS	Quartile	All	0.430	0.235	.006	11	view →
PDAC	OS	Median	II,III,IV	0.632	0.361	.001	11	view →
LUAD	DFS	Median	III,IV	0.316	0.691	.009	7	view →
LSCC	DFS	Quartile	All	0.782	0.564	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRIF1–CCRCC (OS)

Open the CCRCC breakdown →