LRIF1

Across TCGA pan-cancer cohorts, LRIF1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LRIF1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LRIF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRIF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, LUAD, and HNSC are the cancer types where LRIF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRIF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.641	<.001	11	view →
LUAD	Male	III,IV	+1.316	<.001	11	view →
HNSC	All	III,IV	+0.964	<.001	11	view →
LUSC	All	II,III,IV	+0.796	<.001	8	view →
LIHC	Male	All	+0.813	<.001	7	view →
BRCA	All	All	+0.573	<.001	6	view →
KICH	Female	All	−1.042	<.001	5	view →
STAD	Female	All	+1.215	<.001	4	view →
CHOL	Male	All	+1.036	<.001	4	view →
THCA	All	All	−0.301	<.001	4	view →
ESCA	All	All	+0.761	.005	2	view →
COAD	Male	All	+0.475	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LRIF1–BLCA

Open the BLCA breakdown →