LRIF1

Across TCGA patient cohorts, LRIF1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIF1-associated genes across cancer lineages are ATM, ERK2, and JNK_pT183_Y185. Each is linked with LRIF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRIF1-to-partner and partner-to-LRIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LRIF1-low versus LRIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIF1→partner) and Y-score (partner→LRIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.627	-2.201	<.001	<.001	3	3
UCEC	ERK2 →	+0.149	+1.321	.021	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.182	-2.906	.001	.001	3	2
UCEC	P-Cadherin →	-0.111	-1.574	.021	.034	3	2
UCEC	PCNA →	+0.244	+2.502	<.001	.001	2	3
UCEC	Shc_pY317 →	-0.233	-2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by LRIF1 expression — UCEC

Explore this box plot interactively →