LRIF1

Across TCGA cell cohorts, LRIF1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRIF1-associated genes across cancer lineages are IL17A, OR8B4, and REG1B. Each is linked with LRIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIF1-to-partner and partner-to-LRIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17A grouped by LRIF1-low versus LRIF1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIF1→partner) and Y-score (partner→LRIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IL17A →	+0.006	+4.357	<.001	.004	3	1
CNS	OR8B4 →	+0.030	+4.357	<.001	.004	3	1
LARGE_INTESTINE	REG1B →	+3.348	+3.196	<.001	.007	3	1
BLOOD_Leukemia	SLC32A1 →	+0.794	+3.901	<.001	.006	3	1
BLOOD_Leukemia	PPY →	+0.128	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PHOX2B →	+0.020	+4.365	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IL17A by LRIF1 expression — CNS

Explore this box plot interactively →