LRFN5

Across TCGA cell cohorts, LRFN5 mutation is significantly associated with the RNA expression of many other genes, with 253 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRFN5-associated genes across cancer lineages are SLC36A3, PPIAL4A, and BOD1L2. Each is linked with LRFN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN5-to-partner and partner-to-LRFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC36A3 grouped by LRFN5-low versus LRFN5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN5→partner) and Y-score (partner→LRFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC36A3 →	+0.029	+4.564	<.001	.003	3	2
LUNG_SCLC	PPIAL4A →	+0.044	+2.584	.004	.004	3	2
OESOPHAGUS	BOD1L2 →	+0.006	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	ITGAD →	+0.036	+3.125	.004	.008	3	1
BLOOD_Lymphoma	S100A7A →	+0.033	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.032	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 253 associations by consensus.

SLC36A3 by LRFN5 expression — BLOOD_Leukemia

Explore this box plot interactively →