LRFN2

Across TCGA patient cohorts, LRFN2 mutation is significantly associated with the RNA expression of many other genes, with 4,230 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LRFN2-associated genes across cancer lineages are ATAD3A, GAS2L1, and NCKIPSD. Each is linked with LRFN2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRFN2-to-partner and partner-to-LRFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATAD3A grouped by LRFN2-low versus LRFN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN2→partner) and Y-score (partner→LRFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATAD3A →	+0.332	+1.807	.004	<.001	3	5
COAD	GAS2L1 →	+0.598	+2.947	<.001	<.001	3	4
SKCM	NCKIPSD →	+0.310	+1.408	<.001	.002	3	4
UCEC	ESS2 →	+0.219	+1.389	.004	.005	3	4
UCEC	LMF2 →	+0.426	+2.050	<.001	<.001	3	4
UCEC	MIER2 →	+0.321	+2.991	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

ATAD3A by LRFN2 expression — UCEC

Explore this box plot interactively →