LRCH4

Across TCGA patient cohorts, LRCH4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH4-associated genes across cancer lineages are FOXO3a, INPP4B, and MEK1. Each is linked with LRCH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH4-to-partner and partner-to-LRCH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by LRCH4-low versus LRCH4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH4→partner) and Y-score (partner→LRCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.116	-2.459	.020	.018	3	2
UCEC	INPP4B →	-0.251	-1.807	.031	.024	3	2
UCEC	MEK1 →	+0.333	+2.321	.011	.033	3	2
UCEC	MSH2 →	-0.319	-2.105	<.001	.017	3	2
UCEC	MSH6 →	-0.372	-3.459	.001	.005	3	2
UCEC	p62 Lck ligand →	+0.255	+1.495	.029	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FOXO3a by LRCH4 expression — SKCM

Explore this box plot interactively →