LRCH4

Across TCGA pan-cancer cohorts, LRCH4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRCH4 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LRCH4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRCH4 expression acts as an unfavorable survival marker, although some lineages such as ACC and UVM show a favorable association.

COAD, LGG, and ACC are the cancer types where LRCH4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.402	0.614	<.001	77	view →
LGG	DFS	Median	All	0.270	0.483	<.001	48	view →
ACC	OS	Tertile	IV	0.869	0.388	.001	47	view →
UVM	DFS	Median	All	0.737	0.395	.003	41	view →
KIRC	DFS	Quartile	IV	0.183	0.493	.003	40	view →
CESC	DFS	Median	All	0.774	0.872	.005	34	view →
THCA	DFS	Median	IV	0.629	0.919	.002	28	view →
UCS	DFS	Quartile	II,III,IV	0.485	0.224	.007	22	view →
HNSC	DFS	Quartile	IV	0.772	0.557	.003	19	view →
CHOL	DFS	Median	All	0.666	0.180	.001	16	view →
READ	DFS	Tertile	All	0.513	0.747	.012	15	view →
THYM	OS	Median	All	0.960	0.741	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRCH4–COAD (DFS)

Open the COAD breakdown →