LRCH4

Across TCGA cell cohorts, LRCH4 mutation is significantly associated with the drug of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRCH4-associated genes across cancer lineages are Staurosporine, CCT007093, and Niraparib. Each is linked with LRCH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH4-to-partner and partner-to-LRCH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Staurosporine grouped by LRCH4-low versus LRCH4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH4→partner) and Y-score (partner→LRCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Staurosporine →	+0.466	+2.868	.037	.022	2	2
LARGE_INTESTINE	CCT007093 →	+0.302	+2.649	.043	.046	3	1
LARGE_INTESTINE	Niraparib →	+0.376	+2.868	.025	.022	3	1
LARGE_INTESTINE	Fulvestrant →	+0.344	+2.649	.038	.046	3	1
LARGE_INTESTINE	Luminespib →	+0.665	+2.868	.020	.022	3	1
LARGE_INTESTINE	AZD5153 →	+0.584	+2.871	.013	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Staurosporine by LRCH4 expression — LARGE_INTESTINE

Explore this box plot interactively →