LRCH2

Across TCGA cell cohorts, LRCH2 mutation is significantly associated with the mutation status of many other genes, with 2,233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRCH2-associated genes across cancer lineages are COL14A1, PRRC2A, and DMTF1. Each is linked with LRCH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRCH2-to-partner and partner-to-LRCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL14A1 grouped by LRCH2-low versus LRCH2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH2→partner) and Y-score (partner→LRCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	COL14A1 →	+4.044	+5.000	.008	.008	1	4
BLOOD_Lymphoma	PRRC2A →	+3.847	+5.108	.001	.001	1	4
LUNG_NSCLC_LUAD	DMTF1 →	+4.772	+5.339	.004	.004	1	3
CNS	ADARB2 →	+5.044	+5.614	.003	.003	1	3
SKIN	ZNF284 →	+4.824	+5.392	.004	.004	1	3
LUNG_NSCLC_LUAD	ATP11C →	+5.772	+5.772	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,233 associations by consensus.

COL14A1 by LRCH2 expression — CNS

Explore this box plot interactively →