LRCH1

Across TCGA patient cohorts, LRCH1 mutation is significantly associated with the RNA expression of many other genes, with 3,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH1-associated genes across cancer lineages are AQP7P4, NPM1P45, and MIR4774. Each is linked with LRCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH1-to-partner and partner-to-LRCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P4 grouped by LRCH1-low versus LRCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH1→partner) and Y-score (partner→LRCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P4 →	+0.026	+2.384	.002	.007	3	2
LUAD	NPM1P45 →	+0.094	+4.468	.007	.002	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
SKCM	RN7SL305P →	+0.268	+4.801	<.001	.003	3	2
UCEC	MIR6793 →	+0.433	+1.733	.003	.001	3	2
KIRC	RNU6-447P →	+0.233	+8.025	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,870 associations by consensus.

AQP7P4 by LRCH1 expression — UCEC

Explore this box plot interactively →