LRCH1

Across TCGA patient cohorts, LRCH1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH1-associated genes across cancer lineages are STAT5a, ATM, and Chk2_pT68. Each is linked with LRCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH1-to-partner and partner-to-LRCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by LRCH1-low versus LRCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH1→partner) and Y-score (partner→LRCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.471	+3.906	.001	<.001	3	2
UCEC	ATM →	-0.387	-2.700	.017	.006	3	2
UCEC	Chk2_pT68 →	-0.189	-3.077	.004	<.001	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.807	.001	<.001	3	1
UCEC	EGFR →	-0.198	-1.925	<.001	.005	3	1
UCEC	eIF4G →	+0.265	+3.169	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT5a by LRCH1 expression — UCEC

Explore this box plot interactively →