LRATD1

Across TCGA patient cohorts, LRATD1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRATD1-associated genes across cancer lineages are Notch1, eIF4E, and FOXO3a_pS318_S321. Each is linked with LRATD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRATD1-to-partner and partner-to-LRATD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LRATD1-low versus LRATD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRATD1→partner) and Y-score (partner→LRATD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.191	+3.321	.009	.010	3	2
UCEC	eIF4E →	+0.235	+2.820	.033	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.209	-3.321	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.241	-3.308	.006	.010	3	1
UCEC	JNK2 →	+0.341	+2.817	.001	.036	3	1
UCEC	Ku80 →	+0.379	+2.183	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by LRATD1 expression — UCEC

Explore this box plot interactively →