LPP

Across TCGA pan-cancer cohorts, LPP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LPP data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LPP Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LPP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and GBM are the cancer types where LPP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.933	0.304	.012	28	view →
COAD	DFS	Median	All	0.223	0.691	.011	10	view →
GBM	OS	Median	All	0.020	0.416	<.001	6	view →
UCS	OS	Median	All	0.262	0.693	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LPP–UCEC (DFS)

Open the UCEC breakdown →