LPP

Across TCGA pan-cancer cohorts, LPP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LPP data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LPP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LPP expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and GBM are the cancer types where LPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.713	1.000	.004	17	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	OS	Quartile	All	0.641	0.907	.002	8	view →
LUAD	OS	Quartile	All	0.818	0.512	.015	5	view →
HNSC	OS	Quartile	IV	0.688	1.000	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LPP–LSCC (OS)

Open the LSCC breakdown →