LPP

Across TCGA patient cohorts, LPP mutation is significantly associated with the RNA expression of many other genes, with 4,551 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPP-associated genes across cancer lineages are TRAPPC5, UBA7, and ZNF668. Each is linked with LPP in more than 2 cancer types. Because this analysis shows association rather than direction, both LPP-to-partner and partner-to-LPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC5 grouped by LPP-low versus LPP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPP→partner) and Y-score (partner→LPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAPPC5 →	+0.263	+2.364	<.001	.002	3	3
UCEC	UBA7 →	-0.610	-1.726	<.001	.006	3	3
SKCM	ZNF668 →	+0.425	+3.328	.006	.005	3	3
UCEC	R3HCC1 →	+0.444	+2.467	<.001	<.001	3	3
UCEC	PPM1G →	+0.254	+2.047	.009	.001	3	3
UCEC	DOHH →	+0.474	+2.720	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,551 associations by consensus.

TRAPPC5 by LPP expression — UCEC

Explore this box plot interactively →