LPP

Across TCGA cell cohorts, LPP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,544 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LPP-associated GO terms across cancer lineages are Negative regulation of protein-containing complex disassembly, Macroautophagy, and Vacuolar transport. Each is linked with LPP in more than 15 cancer types. Because this analysis shows association rather than direction, both LPP-to-partner and partner-to-LPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex disassembly grouped by LPP-low versus LPP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPP→partner) and Y-score (partner→LPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein-containing complex disassembly →	+0.081	+0.929	<.001	<.001	3	16
OESOPHAGUS	Macroautophagy →	+0.073	+0.799	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.073	+1.124	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to vacuole →	+0.104	+1.123	<.001	<.001	3	14
BONE	Regulation of hippo signaling →	+0.088	+1.479	<.001	.004	3	14
BONE	Response to hydrostatic pressure →	+0.190	+1.642	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,544 associations by consensus.

Negative regulation of protein-containing complex disassembly by LPP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →