LPP

Across TCGA cell cohorts, LPP mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPP-associated genes across cancer lineages are VN1R3, GUCA2A, and USP17L13. Each is linked with LPP in more than 1 cancer types. Because this analysis shows association rather than direction, both LPP-to-partner and partner-to-LPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R3 grouped by LPP-low versus LPP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPP→partner) and Y-score (partner→LPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VN1R3 →	+0.037	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
BLOOD_Leukemia	USP17L13 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	USP17L17 →	+0.004	+4.984	<.001	.002	3	1
OVARY	APOBEC1 →	+0.935	+4.700	<.001	.002	3	1
LARGE_INTESTINE	GCAT →	+1.324	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

VN1R3 by LPP expression — BLOOD_Leukemia

Explore this box plot interactively →