LPP

Across TCGA cell cohorts, LPP mutation is significantly associated with the mutation status of many other genes, with 3,903 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPP-associated genes across cancer lineages are MCM3AP, ADAMTS20, and ANKRD62. Each is linked with LPP in more than 3 cancer types. Because this analysis shows association rather than direction, both LPP-to-partner and partner-to-LPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM3AP grouped by LPP-low versus LPP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPP→partner) and Y-score (partner→LPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MCM3AP →	+3.169	+4.548	.004	.004	1	4
OVARY	ADAMTS20 →	+2.754	+4.095	.009	.009	1	4
LARGE_INTESTINE	ANKRD62 →	+2.409	+2.767	.001	.001	1	4
OVARY	MAP3K9 →	+3.977	+4.930	.001	.001	1	4
OVARY	ZNF317 →	+4.977	+4.415	.007	.007	1	4
LARGE_INTESTINE	SAP130 →	+2.146	+2.321	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,903 associations by consensus.

MCM3AP by LPP expression — SKIN

Explore this box plot interactively →