LPL

Across TCGA cell cohorts, LPL mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPL-associated genes across cancer lineages are GCAT, KLHL2, and TTC33. Each is linked with LPL in more than 1 cancer types. Because this analysis shows association rather than direction, both LPL-to-partner and partner-to-LPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by LPL-low versus LPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPL→partner) and Y-score (partner→LPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.231	+3.364	.002	.002	3	1
LARGE_INTESTINE	KLHL2 →	+0.741	+3.169	<.001	.009	3	1
LARGE_INTESTINE	TTC33 →	+0.597	+3.364	.007	.002	3	1
LARGE_INTESTINE	ID2 →	+1.268	+3.364	.006	.002	3	1
LARGE_INTESTINE	STXBP3 →	+0.442	+3.067	.006	.009	3	1
LARGE_INTESTINE	CTBS →	+0.842	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

GCAT by LPL expression — LARGE_INTESTINE

Explore this box plot interactively →