LPIN2

Across TCGA pan-cancer cohorts, LPIN2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LPIN2 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LPIN2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LPIN2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where LPIN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.656	0.970	<.001	31	view →
CCRCC	DFS	Tertile	All	0.896	0.643	.001	28	view →
LSCC	OS	Tertile	All	0.929	0.842	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

LPIN2–PDAC (OS)

Open the PDAC breakdown →