LPIN2

Across TCGA pan-cancer cohorts, LPIN2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LPIN2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LPIN2 RNA is repressed in tumor relative to normal tissue. In most cancer types LPIN2 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.

LUSC, KIRC, and KICH are the cancer types where LPIN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LPIN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.694	<.001	8	view →
KIRC	Male	II,III,IV	−0.753	<.001	8	view →
KICH	All	All	−1.146	<.001	6	view →
KIRP	Male	All	−0.850	<.001	6	view →
STAD	All	All	+0.825	<.001	6	view →
COAD	Female	All	−0.759	<.001	5	view →
LIHC	All	All	−0.566	.003	4	view →
BLCA	Male	All	−0.976	.007	3	view →
PRAD	All	All	+0.273	.026	2	view →
CHOL	Male	All	−1.118	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LPIN2–LUSC

Open the LUSC breakdown →