LPIN2

Across TCGA patient cohorts, LPIN2 mutation is significantly associated with the RNA expression of many other genes, with 2,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPIN2-associated genes across cancer lineages are CEP76, CENPN, and SAAL1. Each is linked with LPIN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LPIN2-to-partner and partner-to-LPIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP76 grouped by LPIN2-low versus LPIN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN2→partner) and Y-score (partner→LPIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP76 →	+0.609	+3.486	<.001	.002	3	4
UCEC	CENPN →	+0.654	+2.758	<.001	<.001	3	3
UCEC	SAAL1 →	+0.358	+1.551	.005	.002	3	3
UCEC	PBK →	+0.684	+1.541	.001	.002	3	3
UCEC	SCNN1B →	-1.475	-2.584	<.001	<.001	3	3
COAD	PSMA4 →	+0.579	+3.459	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,379 associations by consensus.

CEP76 by LPIN2 expression — COAD

Explore this box plot interactively →