LPIN2

Across TCGA patient cohorts, LPIN2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPIN2-associated genes across cancer lineages are ATM, C-Raf, and MSH6. Each is linked with LPIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPIN2-to-partner and partner-to-LPIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LPIN2-low versus LPIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN2→partner) and Y-score (partner→LPIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.442	-1.986	.002	.029	3	3
COAD	C-Raf →	+0.206	+3.034	.004	.017	3	3
LUSC	MSH6 →	+0.402	+3.179	.046	.010	3	2
UCEC	MEK1 →	+0.450	+2.662	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.136	-1.565	.004	.017	3	2
UCEC	Notch1 →	+0.157	+1.523	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by LPIN2 expression — UCEC

Explore this box plot interactively →