LPIN2

Across TCGA cell cohorts, LPIN2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPIN2-associated genes across cancer lineages are GABRA4, SLC2A7, and TXNDC8. Each is linked with LPIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPIN2-to-partner and partner-to-LPIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRA4 grouped by LPIN2-low versus LPIN2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN2→partner) and Y-score (partner→LPIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GABRA4 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	TXNDC8 →	+0.016	+4.906	<.001	.006	3	1
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
SKIN	KRTAP16-1 →	+0.023	+4.467	<.001	.004	3	1
SKIN	OR6X1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GABRA4 by LPIN2 expression — OESOPHAGUS

Explore this box plot interactively →