LPIN1

Across TCGA cell cohorts, LPIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,113 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LPIN1-associated GO terms across cancer lineages are Negative regulation of phospholipid metabolic process, Triglyceride mobilization, and Nuclear membrane disassembly. Each is linked with LPIN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both LPIN1-to-partner and partner-to-LPIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of phospholipid metabolic process grouped by LPIN1-low versus LPIN1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN1→partner) and Y-score (partner→LPIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of phospholipid metabolic process →	+0.288	+1.383	<.001	<.001	3	17
BREAST	Triglyceride mobilization →	+0.121	+1.150	<.001	<.001	3	15
URINARY_TRACT	Nuclear membrane disassembly →	+0.152	+1.153	<.001	<.001	3	13
URINARY_TRACT	Membrane disassembly →	+0.140	+1.240	<.001	<.001	3	13
SKIN	Cytosolic transport →	+0.077	+1.432	<.001	<.001	3	12
BONE	Vesicle-mediated transport to the plasma membrane →	+0.092	+1.367	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,113 associations by consensus.

Negative regulation of phospholipid metabolic process by LPIN1 expression — BLOOD_Myeloma

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