LPIN1

Across TCGA pan-cancer cohorts, LPIN1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LPIN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LPIN1 RNA is repressed in tumor relative to normal tissue. In most cancer types LPIN1 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where LPIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LPIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.867	<.001	12	view →
HNSC	Male	All	−1.133	<.001	11	view →
COAD	Female	II,III,IV	+0.878	<.001	11	view →
THCA	All	II,III,IV	−0.561	<.001	9	view →
BRCA	All	III,IV	−1.204	<.001	6	view →
KIRP	Male	All	−0.850	<.001	6	view →
LIHC	Male	All	+0.889	<.001	5	view →
BLCA	All	III,IV	−0.837	.022	5	view →
PRAD	All	All	−0.670	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LPIN1–KIRC

Open the KIRC breakdown →