LPIN1

Across TCGA cell cohorts, LPIN1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible LPIN1-associated genes across cancer lineages are RPL10L, HPCAL4, and ZNF804B. Each is linked with LPIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LPIN1-to-partner and partner-to-LPIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL10L grouped by LPIN1-low versus LPIN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPIN1→partner) and Y-score (partner→LPIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RPL10L →	+0.202	+4.191	<.001	.007	3	3
BLOOD_Leukemia	HPCAL4 →	+0.200	+3.825	.001	.002	3	2
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	2
OESOPHAGUS	CABP2 →	+0.023	+4.906	<.001	.006	3	1
SOFT_TISSUE	OR2M5 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	PATE1 →	+0.028	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RPL10L by LPIN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →