LPCAT3

Across TCGA cell cohorts, LPCAT3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible LPCAT3-associated genes across cancer lineages are NOBOX, PF4V1, and LCN9. Each is linked with LPCAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT3-to-partner and partner-to-LPCAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by LPCAT3-low versus LPCAT3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT3→partner) and Y-score (partner→LPCAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	LCN9 →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR4S1 →	+0.063	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	C10orf71 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR1E1 →	+0.046	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

NOBOX by LPCAT3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →