LOXL4

Across TCGA cell cohorts, LOXL4 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LOXL4-associated genes across cancer lineages are SPANXN4, IFNA2, and TTLL2. Each is linked with LOXL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL4-to-partner and partner-to-LOXL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPANXN4 grouped by LOXL4-low versus LOXL4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL4→partner) and Y-score (partner→LOXL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPANXN4 →	+0.107	+4.867	<.001	.009	3	2
LUNG_SCLC	IFNA2 →	+0.019	+5.029	<.001	.006	3	1
BLOOD_Leukemia	TTLL2 →	+0.419	+3.736	<.001	.005	3	1
BLOOD_Leukemia	LRIT1 →	+0.036	+3.684	<.001	.004	3	1
BLOOD_Leukemia	CYP2C19 →	+0.021	+4.889	<.001	<.001	3	1
BLOOD_Leukemia	ASPG →	+0.320	+3.803	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

SPANXN4 by LOXL4 expression — BLOOD_Lymphoma

Explore this box plot interactively →