LOXL4

Across TCGA pan-cancer cohorts, LOXL4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LOXL4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LOXL4 RNA is repressed in tumor relative to normal tissue. In most cancer types LOXL4 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and LIHC are the cancer types where LOXL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LOXL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−4.278	<.001	8	view →
BRCA	All	III,IV	−2.573	<.001	8	view →
LIHC	All	II,III,IV	+1.909	<.001	7	view →
KIRC	Male	II,III,IV	−1.034	<.001	7	view →
COAD	Male	All	−1.009	<.001	7	view →
UCEC	All	All	−2.255	<.001	6	view →
THCA	All	II,III,IV	−0.526	.001	5	view →
CHOL	Female	All	+5.146	<.001	3	view →
READ	Female	All	−1.876	.009	2	view →
KIRP	All	All	−0.740	.018	2	view →
BLCA	Male	III,IV	−1.457	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LOXL4–KICH

Open the KICH breakdown →