LOXL3

Across TCGA patient cohorts, LOXL3 mutation is significantly associated with the RNA expression of many other genes, with 3,953 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL3-associated genes across cancer lineages are LINC00904, HSD17B12, and SLC25A4. Each is linked with LOXL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL3-to-partner and partner-to-LOXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00904 grouped by LOXL3-low versus LOXL3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL3→partner) and Y-score (partner→LOXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC00904 →	+0.249	+3.602	<.001	.004	3	2
UCEC	HSD17B12 →	+0.517	+1.874	<.001	.002	3	2
UCEC	SLC25A4 →	+0.569	+2.917	<.001	<.001	3	2
UCEC	ARL14EP →	+0.410	+3.021	.001	<.001	3	2
UCEC	ATP5F1A →	+0.483	+2.595	<.001	<.001	3	2
UCEC	HOMER1 →	+0.605	+2.917	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,953 associations by consensus.

LINC00904 by LOXL3 expression — BRCA

Explore this box plot interactively →