LOXL1

Across TCGA patient cohorts, LOXL1 mutation is significantly associated with the RNA expression of many other genes, with 909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL1-associated genes across cancer lineages are MTCO2P1, TRBV17, and MTCO2P3. Each is linked with LOXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL1-to-partner and partner-to-LOXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P1 grouped by LOXL1-low versus LOXL1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL1→partner) and Y-score (partner→LOXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MTCO2P1 →	+0.077	+5.305	<.001	.003	3	2
SKCM	TRBV17 →	+0.206	+4.594	<.001	.008	3	2
BLCA	MTCO2P3 →	+0.079	+7.640	<.001	.009	3	2
SKCM	RPL23AP70 →	+0.186	+4.563	<.001	.004	3	2
COAD	MIR6075 →	+0.759	+3.548	<.001	.002	3	2
BLCA	MIR539 →	+0.633	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 909 associations by consensus.

MTCO2P1 by LOXL1 expression — LIHC

Explore this box plot interactively →