LOX

Across TCGA patient cohorts, LOX protein abundance is significantly associated with the RNA expression of many other genes, with 16,103 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LOX-associated genes across cancer lineages are FN1, LOXL2, and ADAMTS12. Each is linked with LOX in more than 9 cancer types. Because this analysis shows association rather than direction, both LOX-to-partner and partner-to-LOX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LOX versus FN1 in OV, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOX→partner) and Y-score (partner→LOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+2.606	+0.909	<.001	<.001	3	10
OV	LOXL2 →	+1.343	+0.909	<.001	<.001	3	10
OV	ADAMTS12 →	+1.815	+0.993	<.001	<.001	3	10
OV	COL6A3 →	+2.147	+0.965	<.001	<.001	3	10
OV	COL5A2 →	+2.355	+0.983	<.001	<.001	3	10
OV	LINC01614 →	+3.236	+0.981	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,103 associations by consensus.

LOX vs FN1 — OV

Explore this scatter interactively →