LOX

Across TCGA pan-cancer cohorts, LOX RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LOX data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher LOX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LOX expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

MESO, STAD, and BLCA are the cancer types where LOX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.420	0.658	<.001	108	view →
STAD	OS	Quartile	All	0.278	0.701	.001	84	view →
BLCA	OS	Tertile	All	0.316	0.520	<.001	74	view →
CESC	DFS	Tertile	III,IV	0.181	0.849	<.001	68	view →
KICH	DFS	Median	All	0.644	1.000	<.001	67	view →
LGG	DFS	Median	All	0.658	0.816	<.001	51	view →
KIRP	OS	Median	All	0.892	0.969	.001	42	view →
LIHC	OS	Tertile	All	0.678	0.843	<.001	32	view →
OV	DFS	Median	II,III,IV	0.487	0.593	<.001	24	view →
PAAD	OS	Tertile	All	0.235	0.543	.006	22	view →
SARC	DFS	Quartile	All	0.489	0.689	.002	18	view →
UVM	OS	Quartile	All	0.894	0.505	.022	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LOX–MESO (OS)

Open the MESO breakdown →