LOX

Across TCGA patient cohorts, LOX mutation is significantly associated with the RNA expression of many other genes, with 1,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOX-associated genes across cancer lineages are ZNF215, NAE1, and ODF3B. Each is linked with LOX in more than 1 cancer types. Because this analysis shows association rather than direction, both LOX-to-partner and partner-to-LOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF215 grouped by LOX-low versus LOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOX→partner) and Y-score (partner→LOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF215 →	+0.741	+3.917	<.001	<.001	3	2
UCEC	NAE1 →	+0.557	+2.807	.004	.003	3	2
UCEC	ODF3B →	-1.355	-3.584	<.001	.002	3	2
UCEC	MKRN2 →	+0.440	+3.209	.004	.009	3	2
UCEC	L2HGDH →	+0.605	+2.818	.001	.001	3	2
BLCA	RNY1P16 →	+1.038	+3.655	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,677 associations by consensus.

ZNF215 by LOX expression — UCEC

Explore this box plot interactively →