LOX

Across TCGA patient cohorts, LOX mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOX-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and GAPDH. Each is linked with LOX in more than 1 cancer types. Because this analysis shows association rather than direction, both LOX-to-partner and partner-to-LOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by LOX-low versus LOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOX→partner) and Y-score (partner→LOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.580	-3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.252	-3.700	.031	.001	3	1
UCEC	GAPDH →	+0.572	+2.584	.022	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.224	-3.321	.004	.010	3	1
UCEC	MIG-6 →	+0.092	+2.598	.047	.006	3	1
UCEC	mTOR_pS2448 →	-0.190	-3.156	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

STAT3_pY705 by LOX expression — UCEC

Explore this box plot interactively →