LOX

Across TCGA cell cohorts, LOX RNA expression is significantly associated with the go_rna of many other GO terms, with 5,341 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LOX-associated GO terms across cancer lineages are Peptidyl-lysine oxidation, Regulation of mesenchymal stem cell proliferation, and Positive regulation of mesenchymal stem cell proliferation. Each is linked with LOX in more than 15 cancer types. Because this analysis shows association rather than direction, both LOX-to-partner and partner-to-LOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine oxidation grouped by LOX-low versus LOX-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LOX→partner) and Y-score (partner→LOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Peptidyl-lysine oxidation →	+1.636	+4.332	<.001	<.001	3	16
BONE	Regulation of mesenchymal stem cell proliferation →	+0.299	+5.103	<.001	<.001	3	13
BONE	Positive regulation of mesenchymal stem cell proliferation →	+0.299	+5.103	<.001	<.001	3	13
BONE	Positive regulation of stress fiber assembly →	+0.171	+3.782	<.001	<.001	3	13
BONE	Protein oxidation →	+1.570	+4.332	<.001	<.001	3	12
BONE	Collagen fibril organization →	+0.351	+4.465	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,341 associations by consensus.

Peptidyl-lysine oxidation by LOX expression — BONE

Explore this box plot interactively →