LOX

Across TCGA cell cohorts, LOX mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LOX-associated genes across cancer lineages are PAX4, PRAMEF1, and CFHR5. Each is linked with LOX in more than 1 cancer types. Because this analysis shows association rather than direction, both LOX-to-partner and partner-to-LOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by LOX-low versus LOX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOX→partner) and Y-score (partner→LOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PAX4 →	+0.017	+4.276	<.001	.007	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.012	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CFHR5 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	ASB10 →	+0.098	+4.551	<.001	.004	3	1
BLOOD_Leukemia	SLC35G3 →	+0.036	+4.874	.001	.002	3	1
BLOOD_Leukemia	GPR101 →	+0.063	+4.551	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PAX4 by LOX expression — BLOOD_Leukemia

Explore this box plot interactively →