LONRF1

Across TCGA patient cohorts, LONRF1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONRF1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and MSH2. Each is linked with LONRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LONRF1-to-partner and partner-to-LONRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LONRF1-low versus LONRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF1→partner) and Y-score (partner→LONRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.277	-1.584	.002	.019	3	2
UCEC	INPP4B →	-0.263	-2.222	.024	.009	3	2
UCEC	MSH2 →	-0.199	-2.433	.016	.018	3	2
UCEC	NF-kB-p65_pS536 →	-0.348	-2.459	.033	.018	3	2
UCEC	STAT3_pY705 →	-0.384	-2.321	<.001	.005	3	2
UCEC	ATM →	-0.508	-2.571	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by LONRF1 expression — UCEC

Explore this box plot interactively →