LONRF1

Across TCGA pan-cancer cohorts, LONRF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LONRF1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LONRF1 RNA is repressed in tumor relative to normal tissue. In most cancer types LONRF1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and BLCA are the cancer types where LONRF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LONRF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.743	<.001	10	view →
LUAD	Female	All	−0.775	<.001	8	view →
BLCA	All	IV	−1.072	.003	7	view →
BRCA	Female	All	−0.741	<.001	6	view →
UCEC	All	All	−0.816	<.001	4	view →
LUSC	All	II,III,IV	−0.656	.003	4	view →
KICH	All	All	+0.709	.003	3	view →
LIHC	All	All	−0.349	.002	3	view →
HNSC	Female	IV	−1.275	.002	2	view →
READ	All	III,IV	+0.725	.035	2	view →
CHOL	All	All	+0.593	.006	2	view →
KIRP	Male	All	−0.516	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LONRF1–THCA

Open the THCA breakdown →