LONRF1

Across TCGA cell cohorts, LONRF1 mutation is significantly associated with the RNA expression of many other genes, with 245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LONRF1-associated genes across cancer lineages are MCM5, EIF3D, and RAB11FIP2. Each is linked with LONRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LONRF1-to-partner and partner-to-LONRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM5 grouped by LONRF1-low versus LONRF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF1→partner) and Y-score (partner→LONRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCM5 →	+0.785	+3.234	.001	.004	3	1
LARGE_INTESTINE	EIF3D →	+0.422	+3.364	.006	.002	3	1
LARGE_INTESTINE	RAB11FIP2 →	+0.606	+3.234	.002	.004	3	1
LARGE_INTESTINE	GPN3 →	+0.642	+3.234	<.001	.004	3	1
LARGE_INTESTINE	NUP107 →	+0.655	+3.364	.001	.002	3	1
LARGE_INTESTINE	WRAP73 →	+0.588	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

MCM5 by LONRF1 expression — LARGE_INTESTINE

Explore this box plot interactively →