LONRF1

Across TCGA cell cohorts, LONRF1 mutation is significantly associated with the mutation status of many other genes, with 3,123 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LONRF1-associated genes across cancer lineages are PLEKHG3, TNC, and MYH7B. Each is linked with LONRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LONRF1-to-partner and partner-to-LONRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHG3 grouped by LONRF1-low versus LONRF1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF1→partner) and Y-score (partner→LONRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLEKHG3 →	+5.437	+5.437	.003	.003	1	3
BONE	TNC →	+5.437	+5.437	.003	.003	1	3
LARGE_INTESTINE	MYH7B →	+1.999	+2.584	<.001	<.001	1	3
SKIN	NOTCH2 →	+3.392	+4.718	.002	.002	1	3
LARGE_INTESTINE	EP300 →	+1.514	+2.184	.005	.005	1	3
OVARY	RSPH6A →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,123 associations by consensus.

PLEKHG3 by LONRF1 expression — BONE

Explore this box plot interactively →