LNX1

Across TCGA patient cohorts, LNX1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LNX1-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and MEK1. Each is linked with LNX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LNX1-to-partner and partner-to-LNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LNX1-low versus LNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNX1→partner) and Y-score (partner→LNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.781	+2.341	<.001	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.183	-2.700	.002	.006	3	2
UCEC	MEK1 →	+0.395	+3.000	.002	<.001	3	2
UCEC	Di-Ras3 →	-0.156	-3.446	.002	.005	3	2
UCEC	eIF4E →	+0.208	+2.392	.005	<.001	3	1
UCEC	ERK2 →	+0.191	+2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by LNX1 expression — UCEC

Explore this box plot interactively →