Across TCGA patient cohorts, LNP1 mutation is significantly associated with the RNA expression of many other genes, with 186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LNP1-associated genes across cancer lineages are HSPE1P10, SUMO2P7, and SRIP1. Each is linked with LNP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LNP1-to-partner and partner-to-LNP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNP1→partner) and Y-score (partner→LNP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HSPE1P10 →	+0.107	+3.014	.003	.009	3	2
SKCM	SUMO2P7 →	+0.251	+3.032	<.001	.009	3	2
SKCM	SRIP1 →	+0.116	+4.665	<.001	<.001	3	1
UCEC	IGKV2-40 →	+0.296	+2.801	<.001	.005	3	1
UCEC	MIR6864 →	+0.612	+2.224	.002	.008	3	1
UCEC	TRBV12-4 →	+0.581	+3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

Exploration

LNP1 survival (RNA) · tumor vs normal (RNA) · all LNP1 data types