LMTK2

Across TCGA cell cohorts, LMTK2 mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMTK2-associated genes across cancer lineages are SLC13A1, NXF5, and FAM149A. Each is linked with LMTK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMTK2-to-partner and partner-to-LMTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC13A1 grouped by LMTK2-low versus LMTK2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMTK2→partner) and Y-score (partner→LMTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC13A1 →	+0.020	+5.614	<.001	.002	3	2
BLOOD_Lymphoma	NXF5 →	+0.099	+3.900	<.001	.006	3	2
BLOOD_Leukemia	FAM149A →	+1.003	+3.309	<.001	.006	3	2
BLOOD_Leukemia	PSEN2 →	-1.529	-3.321	<.001	.005	3	2
LARGE_INTESTINE	HM13 →	-0.505	-3.239	.002	.002	3	2
LARGE_INTESTINE	KRT23 →	-2.223	-2.395	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

SLC13A1 by LMTK2 expression — PANCREAS

Explore this box plot interactively →