LMOD1

Across TCGA patient cohorts, LMOD1 mutation is significantly associated with the RNA expression of many other genes, with 2,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMOD1-associated genes across cancer lineages are PNPLA3, CORO1C, and MRPS15. Each is linked with LMOD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LMOD1-to-partner and partner-to-LMOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA3 grouped by LMOD1-low versus LMOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMOD1→partner) and Y-score (partner→LMOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PNPLA3 →	+0.707	+2.606	<.001	.005	3	3
UCEC	CORO1C →	+0.586	+2.254	<.001	.005	3	3
UCEC	MRPS15 →	+0.388	+2.742	.004	.002	3	3
COAD	SDHB →	+0.664	+3.199	<.001	.009	3	3
UCEC	PSMC3IP →	+0.901	+2.595	<.001	<.001	3	3
UCEC	UQCRH →	+0.947	+3.269	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,767 associations by consensus.

PNPLA3 by LMOD1 expression — UCEC

Explore this box plot interactively →