LMO1

Across TCGA cell cohorts, LMO1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible LMO1-associated genes across cancer lineages are OPRPN, HBM, and GPR171. Each is linked with LMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMO1-to-partner and partner-to-LMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by LMO1-low versus LMO1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMO1→partner) and Y-score (partner→LMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
URINARY_TRACT	HBM →	+0.056	+5.087	<.001	.004	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OPRPN by LMO1 expression — URINARY_TRACT

Explore this box plot interactively →